Increased MPV has been associated with greater in vitro aggregation in response to ADP and collagen. 1 Mean platelet volume (MPV) is a marker of platelet function, ie, large platelets contain more dense granules and produce more thromboxane A 2. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. This association remained significant after adjustment for possible confounding factors (odds ratio=2.2 95% confidence interval, 1.2 to 4.0 P=0.013).Ĭonclusions- Our results indicate that an elevated MPV is associated with a worse outcome for acute ischemic cerebrovascular events independent of other clinical parameters. Results- Patients within the highest quintile of MPV had a significantly higher risk of suffering a severe stroke, defined as modified Rankin Scale score of 3 to 6, compared with patients within the lowest quintile (odds ratio=2.6 95% confidence interval, 1.6 to 4.1 P<0.001). By multivariate logistic regression modeling, we determined the influence of MPV on stroke severity, adjusting for potential confounding factors. Methods- Within a multicenter, cross-sectional study nested in a cohort, we analyzed the relation between MPV and stroke severity as determined by the modified Rankin Scale after 1 week in 776 patients with acute ischemic stroke or transient ischemic attack. If such an association exists, MPV might help to identify patients at increased risk of a severe course of acute cerebrovascular disease. Data from smaller studies regarding an association between MPV and stroke severity and outcome have been controversial. Higher levels of MPV have been found in patients with acute ischemic stroke than in control subjects.
Stroke: Vascular and Interventional Neurology.
Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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